diff --git a/.github/workflows/ci.yaml b/.github/workflows/ci.yaml
index c77f92200..ed7bb43f2 100644
--- a/.github/workflows/ci.yaml
+++ b/.github/workflows/ci.yaml
@@ -84,7 +84,7 @@ jobs:
 
       - name: Run IO tests
         if: always()
-        run: postgrest-with-postgresql-${{ matrix.pgVersion }} -f test/io/fixtures.sql postgrest-test-io
+        run: postgrest-with-postgresql-${{ matrix.pgVersion }} -f test/io/fixtures.sql postgrest-test-io -vv
 
 
   Test-Memory-Nix:
diff --git a/CHANGELOG.md b/CHANGELOG.md
index ed3aca0ab..75396c85c 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -32,6 +32,11 @@ This project adheres to [Semantic Versioning](http://semver.org/).
    + Fixes postgresql resource leak with long-lived connections (#2638)
  - #1569, Allow `any/all` modifiers on the `eq,like,ilike,gt,gte,lt,lte,match,imatch` operators, e.g. `/tbl?id=eq(any).{1,2,3}` - @steve-chavez
    - This converts the input into an array type
+ - #2561, Configurable role settings - @steve-chavez
+   - Database roles that are members of the connection role get their settings applied, e.g. doing
+     `ALTER ROLE anon SET statement_timeout TO '5s'` will result in that `statement_timeout` getting applied for that role.
+   - Works when switching roles when a JWT is sent
+   - Settings can be reloaded with `NOTIFY pgrst, 'reload config'`.
 
 ### Fixed
 
diff --git a/src/PostgREST/CLI.hs b/src/PostgREST/CLI.hs
index 30f59ea39..3443cd3aa 100644
--- a/src/PostgREST/CLI.hs
+++ b/src/PostgREST/CLI.hs
@@ -33,7 +33,7 @@ import Protolude hiding (hPutStrLn)
 main :: App.SignalHandlerInstaller -> Maybe App.SocketRunner -> CLI -> IO ()
 main installSignalHandlers runAppWithSocket CLI{cliCommand, cliPath} = do
   conf@AppConfig{..} <-
-    either panic identity <$> Config.readAppConfig mempty cliPath Nothing
+    either panic identity <$> Config.readAppConfig mempty cliPath Nothing mempty
 
   -- Per https://github.com/PostgREST/postgrest/issues/268, we want to
   -- explicitly close the connections to PostgreSQL on shutdown.
diff --git a/src/PostgREST/Config.hs b/src/PostgREST/Config.hs
index 773745d9d..5bbffb306 100644
--- a/src/PostgREST/Config.hs
+++ b/src/PostgREST/Config.hs
@@ -51,6 +51,7 @@ import Numeric                 (readOct, showOct)
 import System.Environment      (getEnvironment)
 import System.Posix.Types      (FileMode)
 
+import PostgREST.Config.Database         (RoleSettings)
 import PostgREST.Config.JSPath           (JSPath, JSPathExp (..),
                                           dumpJSPath, pRoleClaimKey)
 import PostgREST.Config.Proxy            (Proxy (..),
@@ -99,6 +100,7 @@ data AppConfig = AppConfig
   , configServerUnixSocket         :: Maybe FilePath
   , configServerUnixSocketMode     :: FileMode
   , configAdminServerPort          :: Maybe Int
+  , configRoleSettings             :: RoleSettings
   }
 
 data LogLevel = LogCrit | LogError | LogWarn | LogInfo
@@ -191,13 +193,13 @@ instance JustIfMaybe a (Maybe a) where
 
 -- | Reads and parses the config and overrides its parameters from env vars,
 -- files or db settings.
-readAppConfig :: [(Text, Text)] -> Maybe FilePath -> Maybe Text -> IO (Either Text AppConfig)
-readAppConfig dbSettings optPath prevDbUri = do
+readAppConfig :: [(Text, Text)] -> Maybe FilePath -> Maybe Text -> RoleSettings -> IO (Either Text AppConfig)
+readAppConfig dbSettings optPath prevDbUri roleSettings = do
   env <- readPGRSTEnvironment
   -- if no filename provided, start with an empty map to read config from environment
   conf <- maybe (return $ Right M.empty) loadConfig optPath
 
-  case C.runParser (parser optPath env dbSettings) =<< mapLeft show conf of
+  case C.runParser (parser optPath env dbSettings roleSettings) =<< mapLeft show conf of
     Left err ->
       return . Left $ "Error in config " <> err
     Right parsedConfig ->
@@ -212,8 +214,8 @@ readAppConfig dbSettings optPath prevDbUri = do
       decodeJWKS <$>
         (decodeSecret =<< readSecretFile =<< readDbUriFile prevDbUri parsedConfig)
 
-parser :: Maybe FilePath -> Environment -> [(Text, Text)] -> C.Parser C.Config AppConfig
-parser optPath env dbSettings =
+parser :: Maybe FilePath -> Environment -> [(Text, Text)] -> RoleSettings -> C.Parser C.Config AppConfig
+parser optPath env dbSettings roleSettings =
   AppConfig
     <$> parseAppSettings "app.settings"
     <*> optString "db-anon-role"
@@ -257,6 +259,7 @@ parser optPath env dbSettings =
     <*> (fmap T.unpack <$> optString "server-unix-socket")
     <*> parseSocketFileMode "server-unix-socket-mode"
     <*> optInt "admin-server-port"
+    <*> pure roleSettings
   where
     parseAppSettings :: C.Key -> C.Parser C.Config [(Text, Text)]
     parseAppSettings key = addFromEnv . fmap (fmap coerceText) <$> C.subassocs key C.value
diff --git a/src/PostgREST/Config/Database.hs b/src/PostgREST/Config/Database.hs
index a07eb2e82..8a85c5743 100644
--- a/src/PostgREST/Config/Database.hs
+++ b/src/PostgREST/Config/Database.hs
@@ -3,11 +3,17 @@
 module PostgREST.Config.Database
   ( pgVersionStatement
   , queryDbSettings
+  , queryRoleSettings
   , queryPgVersion
+  , RoleSettings
   ) where
 
+import Control.Arrow ((***))
+
 import PostgREST.Config.PgVersion (PgVersion (..))
 
+import qualified Data.HashMap.Strict as HM
+
 import qualified Hasql.Decoders             as HD
 import qualified Hasql.Encoders             as HE
 import           Hasql.Session              (Session, statement)
@@ -19,6 +25,8 @@ import Text.InterpolatedString.Perl6 (q)
 
 import Protolude
 
+type RoleSettings = (HM.HashMap ByteString [(ByteString, ByteString)])
+
 queryPgVersion :: Bool -> Session PgVersion
 queryPgVersion prepared = statement mempty $ pgVersionStatement prepared
 
@@ -61,5 +69,45 @@ dbSettingsStatement = SQL.Statement sql HE.noParams decodeSettings
     |]
     decodeSettings = HD.rowList $ (,) <$> column HD.text <*> column HD.text
 
+queryRoleSettings :: Bool -> Session RoleSettings
+queryRoleSettings prepared =
+  let transaction = if prepared then SQL.transaction else SQL.unpreparedTransaction in
+  transaction SQL.ReadCommitted SQL.Read $ SQL.statement mempty $ roleSettingsStatement prepared
+
+roleSettingsStatement :: Bool -> SQL.Statement () RoleSettings
+roleSettingsStatement = SQL.Statement sql HE.noParams decodeSettings
+  where
+    sql = [q|
+      with
+      role_setting as (
+        select r.rolname, unnest(r.rolconfig) as setting
+        from pg_auth_members m
+        join pg_roles r on r.oid = m.roleid
+        where member = current_user::regrole::oid
+      ),
+      kv_settings AS (
+        SELECT
+          rolname,
+          substr(setting, 1, strpos(setting, '=') - 1) as key,
+          substr(setting, strpos(setting, '=') + 1) as value
+        FROM role_setting
+      )
+      select rolname, array_agg(row(key, value))
+      from kv_settings
+      group by rolname;
+    |]
+    decodeSettings = HM.fromList . map (bimap encodeUtf8 ((encodeUtf8 *** encodeUtf8) <$>)) <$> HD.rowList aRow
+    aRow :: HD.Row (Text, [(Text, Text)])
+    aRow = (,) <$> column HD.text <*> compositeArrayColumn ((,) <$> compositeField HD.text <*> compositeField HD.text)
+
 column :: HD.Value a -> HD.Row a
 column = HD.column . HD.nonNullable
+
+compositeField :: HD.Value a -> HD.Composite a
+compositeField = HD.field . HD.nonNullable
+
+compositeArrayColumn :: HD.Composite a -> HD.Row [a]
+compositeArrayColumn = arrayColumn . HD.composite
+
+arrayColumn :: HD.Value a -> HD.Row [a]
+arrayColumn = column . HD.listArray . HD.nonNullable
diff --git a/src/PostgREST/Query.hs b/src/PostgREST/Query.hs
index 76e4e9400..23bbf729a 100644
--- a/src/PostgREST/Query.hs
+++ b/src/PostgREST/Query.hs
@@ -237,10 +237,10 @@ optionalRollback AppConfig{..} ApiRequest{iPreferences=Preferences{..}} = do
 -- | Runs local (transaction scoped) GUCs for every request.
 setPgLocals :: AppConfig  -> KM.KeyMap JSON.Value -> Text ->
                ApiRequest -> PgVersion -> DbHandler ()
-setPgLocals conf claims role req actualPgVersion = lift $
+setPgLocals AppConfig{..} claims role req actualPgVersion = lift $
   SQL.statement mempty $ SQL.dynamicallyParameterized
-    ("select " <> intercalateSnippet ", " (searchPathSql : roleSql ++ claimsSql ++ [methodSql, pathSql] ++ headersSql ++ cookiesSql ++ appSettingsSql))
-    HD.noResult (configDbPreparedStatements conf)
+    ("select " <> intercalateSnippet ", " (searchPathSql : roleSql ++ roleSettingsSql ++ claimsSql ++ [methodSql, pathSql] ++ headersSql ++ cookiesSql ++ appSettingsSql))
+    HD.noResult configDbPreparedStatements
   where
     methodSql = setConfigLocal mempty ("request.method", iMethod req)
     pathSql = setConfigLocal mempty ("request.path", iPath req)
@@ -253,12 +253,16 @@ setPgLocals conf claims role req actualPgVersion = lift $
     claimsSql = if usesLegacyGucs
                   then setConfigLocal "request.jwt.claim." <$> [(toUtf8 $ K.toText c, toUtf8 $ unquoted v) | (c,v) <- KM.toList claims]
                   else [setConfigLocal mempty ("request.jwt.claims", LBS.toStrict $ JSON.encode claims)]
-    roleSql = [setConfigLocal mempty ("role", toUtf8 role)]
-    appSettingsSql = setConfigLocal mempty <$> (join bimap toUtf8 <$> configAppSettings conf)
+    roleBs = toUtf8 role
+    roleSql = [setConfigLocal mempty ("role", roleBs)]
+    roleSettingsSql = if null configRoleSettings
+      then mempty
+      else setConfigLocal mempty <$> fromMaybe mempty (HM.lookup roleBs configRoleSettings)
+    appSettingsSql = setConfigLocal mempty <$> (join bimap toUtf8 <$> configAppSettings)
     searchPathSql =
-      let schemas = pgFmtIdentList (iSchema req : configDbExtraSearchPath conf) in
+      let schemas = pgFmtIdentList (iSchema req : configDbExtraSearchPath) in
       setConfigLocal mempty ("search_path", schemas)
-    usesLegacyGucs = configDbUseLegacyGucs conf && actualPgVersion < pgVersion140
+    usesLegacyGucs = configDbUseLegacyGucs && actualPgVersion < pgVersion140
 
     unquoted :: JSON.Value -> Text
     unquoted (JSON.String t) = t
diff --git a/src/PostgREST/Workers.hs b/src/PostgREST/Workers.hs
index c363523e4..28c1cf501 100644
--- a/src/PostgREST/Workers.hs
+++ b/src/PostgREST/Workers.hs
@@ -27,7 +27,8 @@ import Network.Socket.ByteString
 
 import PostgREST.AppState         (AppState)
 import PostgREST.Config           (AppConfig (..), readAppConfig)
-import PostgREST.Config.Database  (queryDbSettings, queryPgVersion)
+import PostgREST.Config.Database  (queryDbSettings, queryPgVersion,
+                                   queryRoleSettings)
 import PostgREST.Config.PgVersion (PgVersion (..), minimumPgVersion)
 import PostgREST.Error            (checkIsFatal)
 import PostgREST.SchemaCache      (querySchemaCache)
@@ -124,7 +125,7 @@ establishConnection appState =
 
     getConnectionStatus :: IO ConnectionStatus
     getConnectionStatus = do
-      pgVersion <- AppState.usePool appState $ queryPgVersion False -- No need to prepare the query here, as the connection might not established
+      pgVersion <- AppState.usePool appState $ queryPgVersion False -- No need to prepare the query here, as the connection might not be established
       case pgVersion of
         Left e -> do
           AppState.logPgrstError appState e
@@ -248,11 +249,22 @@ reReadConfig startingUp appState = do
               killThread (AppState.getMainThreadId appState)
             Nothing -> do
               AppState.logPgrstError appState e
-          pure []
+          pure mempty
         Right x -> pure x
     else
       pure mempty
-  readAppConfig dbSettings configFilePath (Just configDbUri) >>= \case
+  roleSettings <-
+    if configDbConfig then do
+      rSettings <- AppState.usePool appState $ queryRoleSettings configDbPreparedStatements
+      case rSettings of
+        Left e -> do
+          AppState.logWithZTime appState "An error ocurred when trying to query the role settings"
+          AppState.logPgrstError appState e
+          pure mempty
+        Right x -> pure x
+    else
+      pure mempty
+  readAppConfig dbSettings configFilePath (Just configDbUri) roleSettings >>= \case
     Left err   ->
       if startingUp then
         panic err -- die on invalid config if the program is starting up
diff --git a/test/io/fixtures.sql b/test/io/fixtures.sql
index e557a6490..3d66492e2 100644
--- a/test/io/fixtures.sql
+++ b/test/io/fixtures.sql
@@ -98,3 +98,13 @@ as $$
   grant all on table cats to postgrest_test_anonymous;
   notify pgrst, 'reload schema';
 $$;
+
+alter role postgrest_test_anonymous set statement_timeout to '2s';
+alter role postgrest_test_author set statement_timeout to '10s';
+
+create function change_role_statement_timeout(timeout text) returns void as $_$
+begin
+  execute format($$
+    alter role current_user set statement_timeout = %L;
+  $$, timeout);
+end $_$ volatile language plpgsql ;
diff --git a/test/io/test_io.py b/test/io/test_io.py
index 08e6ef5f7..b4a0c8e5e 100644
--- a/test/io/test_io.py
+++ b/test/io/test_io.py
@@ -839,6 +839,40 @@ def test_notify_reloading_catalog_cache(defaultenv):
         assert response.status_code == 200
 
 
+def test_role_settings(defaultenv):
+    "statement_timeout should be set per role"
+
+    env = {
+        **defaultenv,
+        "PGRST_JWT_SECRET": SECRET,
+    }
+
+    with run(env=env) as postgrest:
+        # statement_timeout for postgrest_test_anonymous
+        response = postgrest.session.get("/rpc/get_guc_value?name=statement_timeout")
+        assert response.text == '"2s"'
+
+        # reload statement_timeout with NOTIFY
+        response = postgrest.session.post(
+            "/rpc/change_role_statement_timeout", data={"timeout": "5s"}
+        )
+        assert response.status_code == 204
+
+        response = postgrest.session.get("/rpc/reload_pgrst_config")
+        assert response.status_code == 204
+        time.sleep(0.1)
+
+        response = postgrest.session.get("/rpc/get_guc_value?name=statement_timeout")
+        assert response.text == '"5s"'
+
+        # statement_timeout for postgrest_test_author
+        headers = jwtauthheader({"role": "postgrest_test_author"}, SECRET)
+        response = postgrest.session.get(
+            "/rpc/get_guc_value?name=statement_timeout", headers=headers
+        )
+        assert response.text == '"10s"'
+
+
 # TODO: This test fails now because of https://github.com/PostgREST/postgrest/pull/2122
 # The stack size of 1K(-with-rtsopts=-K1K) is not enough and this fails with "stack overflow"
 # A stack size of 200K seems to be enough for succeess
diff --git a/test/spec/SpecHelper.hs b/test/spec/SpecHelper.hs
index 7fe993412..64d09b3b3 100644
--- a/test/spec/SpecHelper.hs
+++ b/test/spec/SpecHelper.hs
@@ -110,6 +110,7 @@ baseCfg = let secret = Just $ encodeUtf8 "reallyreallyreallyreallyverysafe" in
   , configDbTxAllowOverride     = True
   , configDbTxRollbackAll       = True
   , configAdminServerPort       = Nothing
+  , configRoleSettings          = mempty
   }
 
 testCfg :: AppConfig